This narrative review explores the mechanisms of GLP-1-mediatedglycogenmetabolism and energy expenditure, particularly in key tissues-pancreas, liver, skeletal muscle, and adipose tissue. In thepancreas,GLP-1enhances insulin secretion and beta-cell function.
1-glycogenmetabolism and energy expenditure, particularly in key tissues—pancreas, liver, skeletal muscle, and adipose tissue. In thepancreas,GLP-1enhances insulin secretion and beta-cell function. In the liver, it promotesglycogensynthesisvia insulin-dependent and potential insulin-independent pathways, involving protein kinase B (AKT) and AMP-activated protein kinase (AMPK ...
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This narrative review explores the mechanisms of GLP-1-mediatedglycogenmetabolism and energy expenditure, particularly in key tissues-pancreas, liver, skeletal muscle, and adipose tissue.
GLP-1andits analogs enhance insulin secretion, but thespecificintracellular mechanisms in β-cells remain unclear. Key intracellular mediators including calcium, glutamate, γ-aminobutyric acid, serotonin, and urocortin-3 are modulated byGLP-1signaling with variable and sometimes contradictory effects.
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Duke diabetes and obesity researchers show alpha cells in thepancreasunexpectedly churn out potent, insulin-boostingGLP-1to help control blood sugar.
Here we show,GLP-1R/GCGR dual agonism provides multimodal efficacy to decrease hepatic steatosis and consequently improve insulin sensitivity, in concert with recovery of endogenous β-cell ...
The preproglucagon gene (Gcg) is expressed byspecificenteroendocrine cells (L-cells) of the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the nucleus of the solitary tract. Gcg encodes multiple peptides including glucagon, glucagon-like peptide-1, glucagon-like peptide-2, oxyntomodulin, and glicentin. Of these, glucagon andGLP-1have received the most ...
